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7190687

PIAS1 Polyclonal Antibody, Rockland™

Rabbit Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

PIAS1

Applications

ELISA, Immunofluorescence, Immunoprecipitation, Western Blot

Conjugate

Unconjugated

Host Species

Rabbit

Target Species

Human

Gene Accession No.

O75925

Gene ID (Entrez)

8554

Primary or Secondary

Primary

Product Type

Antibody

Concentration

1 mg/mL

Classification

Polyclonal

Form

Liquid

Regulatory Status

RUO

Formulation

0.01M sodium phosphate with 0.25M NaCl and 0.01% sodium azide; pH 7.2

Gene Alias

2900068C24Rik; AR interacting protein; Ddxbp1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein transferase PIAS1; GBP; Gu binding protein; GU/RH-II; Gu-binding protein; PIAS1; protein inhibitor of activated STAT 1; Protein inhibitor of activated STAT protein 1; protein inhibitor of activated STAT, 1; protein inhibitor of activated STAT-1; RING-type E3 ubiquitin transferase PIAS1; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; ZMIZ3

Gene Symbols

PIAS1

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Gene

PIAS1

Description

  • Store vial at -20°C prior to opening
  • Aliquot contents and freeze at -20°C or below for extended storage
  • Avoid cycles of freezing and thawing
  • Centrifuge product if not completely clear after standing at room temperature
  • This product is stable for several weeks at 4°C as an undiluted liquid
  • Dilute only prior to immediate use
  • A BLAST analysis was used to suggest reactivity to mouse 92.9% homology for the immunogen sequence
  • Cross-reactivity from PIAS1 family and other sources has not been determined
  • PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor
  • This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway
  • It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis
  • The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.