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7190706

SAE1 Polyclonal Antibody, Rockland™

Rabbit Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

SAE1

Applications

ELISA, Western Blot

Conjugate

Unconjugated

Host Species

Rabbit

Target Species

Bovine, Canine, Human, Mouse, Rat

Gene Accession No.

A2VE14, Q6AXQ0, Q9R1T2, Q9UBE0

Gene ID (Entrez)

10055, 308384, 476425, 505512, 56459

Primary or Secondary

Primary

Product Type

Antibody

Concentration

0.41 mg/mL

Classification

Polyclonal

Form

Liquid

Regulatory Status

RUO

Formulation

0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2

Gene Alias

2400010M20Rik; 2610044L12Rik; activator of SUMO1; AL033372; AOS1; AW743391; D7Ertd177e; FLJ3091; HSPC140; SAE1; sentrin/SUMO-activating protein AOS1; SUA1; SUMO-1 activating enzyme E1 N subunit; SUMO1 activating enzyme subunit 1; SUMO-1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; SUMO-activating enzyme subunit 1, N-terminally processed; ubiquitin-like (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; ubiquitin-like protein SUMO-1 activating enzyme; Ubl1a1; Uble1a

Gene Symbols

SAE1

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Gene

SAE1

Description

  • Store vial at -20°C prior to opening
  • Aliquot contents and freeze at -20°C or below for extended storage
  • Avoid cycles of freezing and thawing
  • Centrifuge product if not completely clear after standing at room temperature
  • This product is stable for several weeks at 4°C as an undiluted liquid
  • Dilute only prior to immediate use
  • This purified antibody is directed against human SUMO Activating Enzyme E1 protein
  • This antibody is specific for human SAE1 protein
  • A BLAST analysis using the sequence of the immunizing peptide was used to suggest that this antibody would react with SUMO Activating Enzyme E1 protein from human (100%), bovine, dog, chimpanzee (96%), mouse (93%), and rat (92%) based on a high degree of sequence homology
  • Cross reactivity against this protein from other sources has not been determined
  • Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1), or sumoylation, regulates protein structure and intracellular localization
  • SAE1 and UBA2
  • form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999).