Phospho-Muscle Glycogen Synthase (Ser641) Polyclonal Antibody, Rockland™

Description

• Store vial at -20°C prior to opening
• Aliquot contents and freeze at -20°C or below for extended storage
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• Phospho Glycogen Synthase pS641 antibody is directed against human muscle glycogen synthase
• This phospho specific polyclonal antibody is specific for phosphorylated pS641 of human muscle glycogen synthase
• Reactivity with non-phosphorylated human muscle glycogen synthase is less than 1% by ELISA
• Cross reactivity with muscle glycogen synthase occurs in mouse tissue
• Reactivity with muscle glycogen synthase from other sources has not been determined
• Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP-or TRAF2-mediated transactivation signal
• Increases cell surface CD4(T4) antigen expression
• Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication
• May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production.