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7190993

Phospho-STAT2 (Ser734) Polyclonal Antibody, Rockland™

Rabbit Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Phospho-STAT2 (Ser734)

Applications

ELISA, Western Blot

Conjugate

Unconjugated

Host Species

Rabbit

Target Species

Human, Monkey

Gene Accession No.

P52630

Gene ID (Entrez)

6773

Primary or Secondary

Primary

Product Type

Antibody

Concentration

0.64 mg/mL

Classification

Polyclonal

Form

Liquid

Regulatory Status

RUO

Formulation

0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2

Gene Alias

1600010G07Rik; AW496480; BOS_5470; IMD44; interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT; STAT 2; STAT113; STAT2; STAT-2

Gene Symbols

Stat2

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Gene

Stat2

Description

  • Store vial at -20°C prior to opening
  • Aliquot contents and freeze at -20°C or below for extended storage
  • Avoid cycles of freezing and thawing
  • Centrifuge product if not completely clear after standing at room temperature
  • This product is stable for several weeks at 4°C as an undiluted liquid
  • Dilute only prior to immediate use
  • STAT2 pS734 affinity purified antibody is directed against human STAT2 protein
  • This antibody is specific for phosphorylated S734 human STAT2
  • A BLAST analysis was used to suggest cross-reactivity with STAT2 pS734 protein from human and monkey sources based on homology with the immunizing sequence
  • Reactivity against homologues from other sources is not known
  • STAT2 is a member of the STAT protein family
  • In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators
  • In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly
  • Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.