CCL2 Polyclonal Antibody, Rockland™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CCL2
Applications
ELISA, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Bovine
Gene Accession No.
P28291
Gene ID (Entrez)
281043
Immunogen
This protein-A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein raised in yeast, corresponding to the 76 amino acids of the mature bovine CCL2 protein.
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Gene
Ccl2
Concentration
1 mg/mL
Classification
Polyclonal
Form
Lyophilized
Regulatory Status
RUO
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias
Acidic seminal fluid protein; AI323594; BOS_18463; C-C motif chemokine 2; C-C motif chemokine ligand 2; Ccl2; chemokine (C-C motif) ligand 2; GDCF-2; HC11; H-MCP-1; HSMCR30; immediate-early serum-responsive JE protein; Immediate-early serum-responsive protein JE; Je; MCAF; Mcp1; MCP-1; MCP1A; MCP-1A; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte chemotactic protein 1A; Monocyte secretory protein JE; Platelet-derived growth factor-inducible protein JE; RP23-350G1.3; Scya2; Sigje; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible gene JE; Small-inducible cytokine A2; SMC-CF
Gene Symbols
Ccl2
Primary or Secondary
Primary
Product Type
Antibody
Related Products
Description
- Store vial at 4°C prior to restoration
- For extended storage aliquot contents and freeze at -20°C or below
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This antibody is specific for bovine CCL2 protein
- A BLAST analysis was used to suggest cross-reactivity with CCL2 from bovine sources based on 100% homology with the immunizing sequence
- Partial reactivity is expected against Sus scrofa 85.5% and Bos Taurus 81.1%
- Cross-reactivity with CCL2 from other sources has not been determined
- This gene is one of several cytokine genes clustered on the q-arm of chromosome 17
- Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes
- The protein encoded by this gene is structurally related to the CXC subfamily of cytokines
- Members of this subfamily are characterized by two cysteines separated by a single amino acid
- This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils
- It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis
- It binds to chemokine receptors CCR2 and CCR4.