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7193112

CD63 Monoclonal Antibody (NVG-2), PE, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

CD63

Concentration

0.2 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Alias

C75951; CD 63; Cd63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Cd63 molecule; CD63 protein; granulophysin; LAMP-3; Lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; mast cell antigen AD1; ME491; melanoma 1 antigen; melanoma-associated antigen ME491; melanoma-associated antigen MLA1; MLA1; Ocular melanoma-associated antigen; OMA81H; Tetraspanin-30; TSPAN30; tspan-30

Gene Symbols

CD63

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Gene

CD63

Clone

NVG-2

Applications

Flow Cytometry

Conjugate

PE

Host Species

Rat

Target Species

Mouse

Gene Accession No.

P41731

Gene ID (Entrez)

12512

Isotype

IgG2a κ

Purification Method

Affinity chromatography

Product Type

Antibody

Description

  • Rat Monoclonal Antibody CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types
  • CD63 is also present in the plasma membrane, usually following cell activation
  • Hence, CD63 has become a widely used basophil activation marker
  • In mast cells, however, CD63 exposition does not need their activation
  • CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels
  • CD63 also serves as a T-cell costimulation molecule
  • Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas
  • CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation
  • CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells
  • CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40
  • Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.