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7193195

CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE-Cyanine7, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

CD365 (TIM1)

Concentration

5 μL/Test

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Alias

AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1

Gene Symbols

Havcr1

Isotype

IgG1 κ

Purification Method

Affinity chromatography

Product Type

Antibody

Clone

1D12-TIM1

Applications

Flow Cytometry

Conjugate

PE-Cyanine7

Host Species

Mouse

Target Species

Human

Gene Accession No.

Q96D42

Gene ID (Entrez)

26762

Immunogen

IgV domain of human CD365

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Gene

Havcr1

Description

  • Mouse Monoclonal Antibody CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail
  • The endogenous ligand for CD365 is Tim-4
  • In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus
  • The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes
  • Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity
  • CD365 has also been implicated in the T cell co-stimulation
  • CD365 is primarily expressed in epithelial cells
  • It is also highly expressed in A549, 769-P and Caco-2 and cell lines
  • CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.