72-029-5
MC4R Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 72-029-5-Each-of-1 | In Stock | ₹ 44,633.50 |
72-029-5 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,633.50
GST (18%): ₹ 8,034.03
Total Price: ₹ 52,667.53
Antigen
MC4R
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MC4R
Gene Alias
MC4; MC4 receptor; mc4r; Mc4-r; melanocortin 4 receptor; melanocortin receptor 4; si:dkey-151m6.62; zMC4
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4160
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.1% BSA, 30% glycerol and 0.09% sodium azide; pH 7.2
Gene Accession No.
P32245
Gene Symbols
MC4R
Immunogen
Peptide corresponding to Human MC4R (aa 20-34)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides
- The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide
- The purified antibody is tested for its functionality in various relevant research applications
- The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature
- This antibody is predicted to react with Monkey, Cat and Pig
- Expression of MC4R has been reported in brain
- Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes
- G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist
- All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms
- An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors
- Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs
- This "eturn-off"e activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates
- Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.