7214617
TNF Mouse, anti-Human, R718, Clone: MAB11, BD Horizon™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TNF
Applications
Flow Cytometry
Conjugate
R718
Host Species
Mouse
Target Species
Human
Content And Storage
Refrigerate Upon Arrival
Clone
MAB11
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Primary or Secondary
Primary
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Description
- Description The MAb11 monoclonal antibody specifically binds to human tumor necrosis factor (TNF, also known as TNF-α) protein
- TNF is an efficient juxtacrine, paracrine and endocrine mediator of inflammatory and immune functions
- It regulates the growth and differentiation of a variety of cell types
- TNF is cytotoxic for transformed cells when in conjunction with IFN-γ
- It is secreted by activated monocytes/macrophages and other cells such as B cells, T cells and fibroblasts
- The immunogen used to generate the MAb11 hybridoma was recombinant human TNF
- The MAb11 antibody has been reported to crossreact with Rhesus Macaque TNF.