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7215084

Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), FITC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Phospho-CREB (Ser133)

Applications

Flow Cytometry

Conjugate

FITC

Host Species

Rabbit

Target Species

Human, Mouse

Gene Accession No.

P16220, Q01147

Gene ID (Entrez)

12912, 1385

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Ser133 of human phospho CREB.

Primary or Secondary

Primary

Content And Storage

4° C, store in dark

Gene

CREB1

Clone

CREBS133-4D11

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.20% BSA and 0.09% sodium azide

Gene Alias

2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein

Gene Symbols

CREB1

Isotype

IgG κ

Purification Method

Protein A/G

Product Type

Antibody

Description

  • CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors
  • Activation of CREB is dependent upon the phosphorylation of serine 133
  • Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1
  • Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor
  • CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133
  • CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory
  • In humans, the gene is located on the q arm of chromosome 2
  • Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.