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7215184

Phospho-EGFR (Tyr1068) Recombinant Rabbit Monoclonal Antibody (EGFRY1068-E5), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Phospho-EGFR (Tyr1068)

Concentration

0.5 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide

Gene Alias

2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2

Gene Symbols

EGFR

Isotype

IgG κ

Purification Method

Protein A/G

Product Type

Antibody

Clone

EGFRY1068-E5

Applications

Flow Cytometry

Conjugate

Unconjugated

Host Species

Rabbit

Target Species

Human, Mouse, Rat

Gene Accession No.

P00533, Q01279

Gene ID (Entrez)

13649, 1956, 24329

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human phospho EGFR.

Primary or Secondary

Primary

Content And Storage

-20°C

Gene

EGFR

Description

  • EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors
  • Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics
  • EGFR is encoded by the EGFR gene located on chromosome 7 in humans
  • EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4
  • EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain
  • Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.