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7218461

Ly-6G/Ly-6C Monoclonal Antibody (RB6-8C5), eFluor™ 506, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Ly-6G/Ly-6C

Concentration

0.2 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Alias

AA682074; AA959465; Gr1; Gr-1; Granulocyte Marker; Ly6c; Ly-6C; Ly-6C.2; Ly6c1; Ly-6C1; Ly6c2; Ly-6C2; Ly6g; Ly-6G; ly-6G.1; lymphocyte antigen 6 complex, locus C; lymphocyte antigen 6 complex, locus C1; lymphocyte antigen 6 complex, locus C2; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6C precursor (Ly-6C); lymphocyte antigen 6C1; Lymphocyte antigen 6C2; lymphocyte antigen 6G; Lymphocyte antigen Ly-6C; lymphocyte differentiation antigen; PML; PMN

Gene Symbols

Ly6c1, Ly6c2, Ly6g

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Clone

RB6-8C5

Applications

Flow Cytometry

Conjugate

eFluor 506

Host Species

Rat

Target Species

Mouse

Gene Accession No.

P0CW02, P0CW03, P35461

Gene ID (Entrez)

100041546, 17067, 546644

Isotype

IgG2b κ

Purification Method

Affinity chromatography

Product Type

Antibody

Description

  • The RB6-8C5 MAb reacts with mouse Ly-6G, a 21-25 kDa protein also known as the myeloid differentiation antigen Gr-1
  • A GPI-linked protein, Gr-1 is expressed by the myeloid lineage in a developmentally regulated manner in the bone marrow
  • While monocytes only express Gr-1 transiently during their bone marrow development, the expression of Gr-1 on bone marrow granulocytes as well as on peripheral neutrophils is a good marker for these populations
  • eBioscience testing indicates that in the bone marrow and lysed whole blood, the antibody clone RB6-8C5 also stains cells that express the highest levels of Ly6c (as defined by staining with antibody clone HK1.4)
  • It is recommended that 1A8-Ly6G (cat
  • 9668) be used when looking at Ly-6G specific targets
  • Granulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm
  • They are also called polymorphonuclear leukocytes (PMN or PML) because of the varying shapes of the nucleus, which is usually lobed into three segments
  • In common parlance, the term polymorphonuclear leukocyte often refers specifically to neutrophil granulocytes, the most abundant of the granulocytes
  • Granulocytes or PMN are released from the bone marrow by the regulatory complement proteins.