CD11c Monoclonal Antibody (N418), Brilliant Ultra Violet™ 737, eBioscience™, Invitrogen™
Armenian Hamster Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD11c
Concentration
0.2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Alias
AI449405; CD11 antigen-like family member C; CD11c; CD11C (p150) alpha polypeptide; complement component 3 receptor 4 subunit; complement receptor 4; Cr4; integrin alpha X; integrin alpha-X; integrin aX; integrin subunit alpha X; integrin, alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); Itgax; Leu M5; leu M5, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; myeloid membrane antigen, alpha subunit; N418; p150 95 integrin alpha chain; RGD1561123; SLEB6
Gene Symbols
Itgax
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Gene
Itgax
Clone
N418
Applications
Flow Cytometry
Conjugate
Brilliant Ultraviolet 737
Host Species
Armenian Hamster
Target Species
Mouse
Gene Accession No.
Q9QXH4
Gene ID (Entrez)
16411
Isotype
IgG
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- The N418 monoclonal antibody reacts with mouse CD11c, the integrin alphaX
- CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer
- CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells
- CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions
- N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer
- Applications Reported: This N418 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This N418 antibody has been tested by flow cytometric analysis of mouse splenocytes
- This may be used at less than or equal to 0.5 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Brilliant Ultraviolet 737 is a tandem dye that emits at 732 nm and is intended for use on cytometers equipped with an ultraviolet (355 nm) laser
- CD11, along with CD18, form a heterodimer adhesion molecule
- In particular, CD11 is composed of CD11a, CD11b and CD11c
- CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils
- CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes
- CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.