E-selectin Recombinant Rabbit Monoclonal Antibody (40), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
E-selectin
Concentration
1 mg/mL
Classification
Recombinant Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative
Gene Alias
CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Gene Symbols
SELE
Isotype
IgG
Purification Method
Protein A
Product Type
Antibody
Clone
40
Applications
ELISA, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P16581
Gene ID (Entrez)
6401
Immunogen
Recombinant Human CD62E protein.
Primary or Secondary
Primary
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Gene
SELE
Related Products
Description
- Specificity: Human E-selectin/SELE/CD62E Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes
- In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation
- This response is immediate and involves a cascade of adhesion receptors
- At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade
- Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium
- E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines
- In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade
- E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.