CD86 (B7-2) Monoclonal Antibody (12), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD86 (B7-2)
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative
Gene Alias
activation B7-2 antigen; B lymphocyte activation antigen B72; B7; B7.2; B70; B7-2; B-lymphocyte activation antigen B7-2; BU63; CD28 antigen ligand 2; Cd28l2; CD28LG2; CD86; CD86 antigen; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CD86 antigen precursor; CD86 molecule; CLS1; CTLA-4 counter-receptor B7.2; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1; Early T-cell co-stimulatory molecule 1; ETC-1; FUN-1; LAB72; Ly58; Ly-58; MB7; MB7-2; membrane glycoprotein; MGC34413; T-lymphocyte activation antigen CD86; TS/A-2
Gene Symbols
CD86
Isotype
IgG1
Purification Method
Protein A
Product Type
Antibody
Clone
12
Applications
ELISA
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Rat
Gene Accession No.
0
Gene ID (Entrez)
56822
Immunogen
Recombinant Rat CD86/B7-2 Protein.
Primary or Secondary
Primary
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Gene
CD86
Related Products
Description
- Specificity: Rat CD86/B7-2 CD86 is one of two ligands (the other CD80) for CTLA4 and CD28
- CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation
- Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance
- CD80 appears to play a role distinct from CD80 in T helper cell differentiation
- CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily
- The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4
- Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell
- Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response
- Alternative splicing results in two transcript variants encoding different isoforms of CD86
- Additional transcript variants have been described for CD86, but their full-length sequences have not been determined
- Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.