CD244 Recombinant Rabbit Monoclonal Antibody (031), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD244
Concentration
1 mg/mL
Classification
Recombinant Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative
Gene Alias
2B4; C9.1; CD244; CD244 long isoform; CD244 molecule; Cd244 molecule, natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; CD244 short isoform; F730046O15Rik; h2B4; Ly90; NAIL; natural killer cell receptor 2B4; NK cell activation inducing ligand NAIL; NK cell activation-inducing ligand; NK cell receptor 2B4; NK cell type I receptor protein 2B4; NKR Nmrk; NKR2B4; Nmrk; non MHC restricted killing associated; non-MHC restricted killing associated; Signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4; transmembrane NK cell receptor 2B4
Gene Symbols
CD244
Isotype
IgG
Purification Method
Protein A
Product Type
Antibody
Clone
031
Applications
ELISA
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q9BZW8
Gene ID (Entrez)
51744
Immunogen
Recombinant Human 2B4/CD244 Protein.
Primary or Secondary
Primary
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Gene
CD244
Related Products
Description
- Specificity: Human 2B4/CD244 CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing
- The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity
- CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells
- Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease
- Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome
- Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.