CD134 (OX40) Monoclonal Antibody (OX-86), Super Bright™ 780, eBioscience™, Invitrogen™
Manufacturer: eBioscience
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 78-134-182-Each-of-1 | In Stock | ₹ 33,553.00 |
78-134-182 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,553.00
GST (18%): ₹ 6,039.54
Total Price: ₹ 39,592.54
Antigen
CD134 (OX40)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P47741
Gene Symbols
Tnfrsf4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22163
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
OX-86
Conjugate
Super Bright 780
Gene
Tnfrsf4
Gene Alias
ACT35; ACT35 antigen; ATC35 antigen; CD134; CD134 antigen; IMD16; Ly-70; lymphoid activation antigene ACT35; MRC OX40; Ox40; OX40 antigen; OX40 cell surface antigen; OX40 homologue; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 receptor; TNF receptor superfamily member 4; Tnfrsf4; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor receptor superfamily member 4; tumor necrosis factor receptor superfamily, member 4; tumor necrosis factor superfamily, member 4; Txgp1; Txgp1l
Host Species
Rat
Quantity
100μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG1 κ
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Description
- Description: This 1RNM44N monoclonal antibody recognizes mouse CD170, also known as Siglec F
- Siglec F is a cell surface lectin belonging to the Ig superfamily that binds glycoconjugates containing sialic acids that are commonly found on various cell types
- The cytoplasmic domain of Siglec F contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) that initiates intracellular signaling upon ligand binding
- Siglec F is expressed mostly on eosinophils and alveolar macrophages and lower levels of this receptor have also been reported on immature myelomonocytic cells
- Mouse Siglec F is a functional ortholog of human Siglec 8, however, unlike human Siglec 8, mouse Siglec F is not expressed on mast cells
- This 1RNM44N antibody will recognize a formaldehyde-fixed epitope
- Applications Reported: This 1RNM44N antibody has been reported for use in flow cytometric analysis
- Applications Tested: This 1RNM44N antibody has been tested by flow cytometric analysis of mouse thioglycolate-elicited peritoneal exudate cells
- This can be used at less than or equal to 0.5 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- OX40 is a protein receptor found on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system
- When activated, OX40 promotes the proliferation and survival of T cells, leading to a stronger immune response against cancer cells and infectious agents
- OX40 agonists, which are drugs that activate OX40, have shown promising results in preclinical and clinical studies as a potential immunotherapy for cancer
- They can enhance the efficacy of other cancer treatments such as chemotherapy and checkpoint inhibitors, and may also have applications in autoimmune diseases and allergies.