89-000-932
retinoic acid receptor, alpha, Mouse, Clone: 2D2, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-000-932-Each-of-1 | In Stock | ₹ 40,851.00 |
89-000-932 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,851.00
GST (18%): ₹ 7,353.18
Total Price: ₹ 48,204.18
Antigen
retinoic acid receptor, alpha
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
NM_000964
Gene Symbols
RARA
Immunogen
RARA (NP_000955, 315 a.a. ∼ 424 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Quantity
100 μg
Research Discipline
Transcription Regulation
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Applications
ELISA, Immunohistochemistry (PFA fixed), Western Blot
Clone
2D2
Description
Mouse monoclonal antibody raised against a partial recombinant RARA.
Gene
RARA
Gene Alias
NR1B1/RAR
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Whole Molecule
Yes
Gene ID (Entrez)
5914
Content And Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype
IgG1 κ
Related Products
Description
- Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers
- In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241)
- When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery
- Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376)
- The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM Sequence: QLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLS