89-005-690
anti-LAMA4 Ab-2, Polyclonal, Abnova
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-005-690-Each-of-1 | In Stock | ₹ 42,898.00 |
89-005-690 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,898.00
GST (18%): ₹ 7,721.64
Total Price: ₹ 50,619.64
Antigen
laminin, alpha 4
Classification
Polyclonal
Description
Mouse polyclonal antibody raised against a full-length human LAMA4 protein.
Gene
LAMA4
Gene Alias
DKFZp686D23145/LAMA3/LAMA4*-1
Host Species
Mouse
Quantity
50 μL
Whole Molecule
Yes
Gene ID (Entrez)
3910
Content And Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Applications
Western Blot
Conjugate
Unconjugated
Formulation
No additive
Gene Accession No.
BC004241.1
Gene Symbols
LAMA4
Immunogen
LAMA4 (AAH04241.1, 1 a.a. ∼ 120 a.a) full-length human protein.
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Serum
Related Products
Description
- Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes
- They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis
- Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains
- Each laminin chain is a multidomain protein encoded by a distinct gene
- Several isoforms of each chain have been described
- Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e
- alpha1beta1gamma1 heterotrimer is laminin 1
- The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo
- This gene encodes the alpha chain isoform laminin, alpha 4
- The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost
- Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains
- The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known
- Tissue-specific utilization of alternative polyA-signal has been described in literature
- Also, alternative splicing involving the first intron in the 5' UTR, and laminin alpha 4 like isoforms have been noted, however, the full-length nature of these products is not known
- Detection Antibody, Western Blotting