89-021-422
ELA2 (M06J), Mouse anti-Human, Clone: 3B1, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-021-422-Each-of-1 | In Stock | ₹ 52,421.00 |
89-021-422 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,421.00
GST (18%): ₹ 9,435.78
Total Price: ₹ 61,856.78
Antigen
ELA2
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
NM_001972
Gene Symbols
ELA2
Immunogen
ELA2 (NP_001963, 168 a.a. ∼ 267 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
ELISA
Clone
3B1
Description
Mouse monoclonal antibody raised against a partial recombinant ELA2.
Gene
ELA2
Gene Alias
GE/HLE/HNE/NE/PMN-E
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1991
Content And Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Form
Liquid
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Description
- Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin
- Humans have six elastase genes which encode the structurally similar proteins
- The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils
- The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix
- This protein degrades the outer membrane protein A (OmpA) of E
- coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia
- Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN)
- This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter
- All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation
- [provided by RefSeq] Sequence: VLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH