89-104-640

HLA-DOB, Mouse, Polyclonal Antibody, Abnova™

Manufacturer: Abnova Corporation

Select a Size

Pack Size SKU Availability Price
Each of 1 89-104-640-Each-of-1 In Stock ₹ 30,794.00

89-104-640 - Each of 1

₹ 30,794.00

In Stock

Quantity

1

Base Price: ₹ 30,794.00

GST (18%): ₹ 5,542.92

Total Price: ₹ 36,336.92

Antigen

HLA-DOB

Classification

Polyclonal

Description

Mouse polyclonal antibody raised against a partial recombinant HLA-DOB.

Gene

HLA-DOB

Gene Alias

DOB

Host Species

Mouse

Quantity

50 μL

Primary or Secondary

Primary

Target Species

Human

Form

Antisera

Applications

ELISA, Western Blot

Conjugate

Unconjugated

Formulation

50% glycerol

Gene Accession No.

NM_002120

Gene Symbols

HLA-DOB

Immunogen

HLA-DOB (NP_002111, 27 a.a. ∽ 116 a.a) partial recombinant protein with GST tag.

Regulatory Status

RUO

Gene ID (Entrez)

3112

Content And Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

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Description

  • HLA-DOB belongs to the HLA class II beta chain paralogues
  • This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane
  • It is located in intracellular vesicles
  • DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM
  • Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages)
  • The beta chain is approximately 26-28kDa and its gene contains 6 exons
  • Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail
  • [provided by RefSeq Sequence: TDSPEDFVIQAKADCYFTNGTEKVQFVVRFIFNLEEYVRFDSDVGMFVALTKLGQPDAEQWNSRLDLLERSRQAVDGVCRHNYRLGAPFT