89-104-913
MAP3K4, Mouse, Clone: X1, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-104-913-Each-of-1 | In Stock | ₹ 42,898.00 |
89-104-913 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,898.00
GST (18%): ₹ 7,721.64
Total Price: ₹ 50,619.64
Antigen
MAP3K4
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
ascites with no preservative
Gene Accession No.
NM_005922
Gene Symbols
MAP3K4
Immunogen
MAP3K4 (NP_005913,1201 a.a. ∽ 1300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Regulatory Status
RUO
Gene ID (Entrez)
4216
Content And Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Form
Ascites
Applications
ELISA, Western Blot
Clone
X1
Description
Mouse monoclonal antibody raised against a partial recombinant MAP3K4.
Gene
MAP3K4
Gene Alias
FLJ42439/KIAA0213/MAPKKK4/MEKK4/MTK1/PRO0412
Host Species
Mouse
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Related Products
Description
- The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK
- While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors
- This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1
- This protein contains a protein kinase catalytic domain at the C terminus
- The N-terminal nonkinase domain may contain a regulatory domain
- Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway
- In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs
- MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway
- Two alternatively spliced transcripts encoding distinct isoforms have been described
- [provided by RefSeq Sequence: AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS