89-114-334
F12, Sheep, Polyclonal Antibody, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-114-334-Each-of-1 | In Stock | ₹ 53,133.00 |
89-114-334 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,133.00
GST (18%): ₹ 9,563.94
Total Price: ₹ 62,696.94
Antigen
F12
Classification
Polyclonal
Description
Sheep polyclonal antibody raised against native F12.
Formulation
In PBS (50% glycerol)
Gene Alias
HAE3/HAEX/HAF
Host Species
Sheep
Quantity
1 mg
Primary or Secondary
Primary
Test Specificity
This antibody recognizes human factor XII.
Content And Storage
Store at -20°C.Aliquot to avoid repeated freezing and thawing.
Applications
ELISA, Western Blot
Conjugate
Unconjugated
Dilution
Western Blot (25 ug/mL) The optimal working dilution should be determined by the end user.
Gene
F12
Gene Symbols
F12
Immunogen
Native purified Human F12.
Regulatory Status
RUO
Gene ID (Entrez)
2161
Target Species
Human
Form
Liquid
Related Products
Description
- This gene encodes coagulation factor XII which circulates in blood as a zymogen
- This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain
- The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain
- On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain
- Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa
- The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin
- It activates coagulation factors VII and XI
- Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged
- [provided by RefSeq