89-114-482

AKT1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Manufacturer: Abnova Corporation

Select a Size

Pack Size SKU Availability Price
Each of 1 89-114-482-Each-of-1 In Stock ₹ 53,133.00

89-114-482 - Each of 1

₹ 53,133.00

In Stock

Quantity

1

Base Price: ₹ 53,133.00

GST (18%): ₹ 9,563.94

Total Price: ₹ 62,696.94

Antigen

AKT1

Classification

Polyclonal

Description

Rabbit polyclonal antibody raised against a synthetic peptide of AKT1.

Formulation

In PBS (0.2% gelatin, 0.09% sodium azide)

Gene Alias

AKT/MGC99656/PKB/PKB-ALPHA/PRKBA/RAC/RAC-ALPHA

Host Species

Rabbit

Quantity

200 μg

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Form

Liquid

Applications

Immunohistochemistry (Frozen), Western Blot

Conjugate

Unconjugated

Dilution

The optimal working dilution should be determined by the end user.

Gene

AKT1

Gene Symbols

AKT1

Immunogen

A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human AKT1.

Regulatory Status

RUO

Gene ID (Entrez)

207

Content And Storage

Store at 4°C. Do not freeze.

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Description

  • The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts
  • AKT1 and the related AKT2 are activated by platelet-derived growth factor
  • The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1
  • It was shown that the activation occurs through phosphatidylinositol 3-kinase
  • In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival
  • Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery
  • Multiple alternatively spliced transcript variants have been found for this gene
  • [provided by RefSeq