ERBB2 Mouse anti-Human, Clone: ERB2/776, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-934-109-Each-of-1 | In Stock | ₹ 67,551.00 |
89-934-109 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 67,551.00
GST (18%): ₹ 12,159.18
Total Price: ₹ 79,710.18
Antigen
ERBB2
Classification
Monoclonal
Conjugate
Unconjugated
Dilution
Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Gene Alias
CD340/HER-2/HER-2/neu/HER2/NEU/NGL/TKR1
Host Species
Mouse
Purification Method
Protein A/G purification
Regulatory Status
RUO
Gene ID (Entrez)
2064
Target Species
Human
Form
Liquid
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Clone
ERB2/776
Description
Mouse monoclonal antibody raised against partial recombinant human ERBB2.
Formulation
In 10mM PBS.
Gene Symbols
ERBB2
Immunogen
Recombinant protein corresponding to intracellular domain of human ERBB2.
Quantity
100 μg
Primary or Secondary
Primary
Test Specificity
This monoclonal antibody is specific to ERBB2 and shows minimal cross-reaction with other members of the family.
Content And Storage
Store at -20 to -80°C.Aliquot to avoid repeated freezing and thawing.
Isotype
IgG1 κ
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Description
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases
- This protein has no ligand binding domain of its own and therefore cannot bind growth factors
- However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase
- Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here
- Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors
- Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized
- [provided by RefSeq]