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A21328

Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody (RC6F8), Invitrogen™

Manufacturer: Invitrogen

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Pack Size SKU Availability Price
Each of 1 A21328-Each-of-1 In Stock ₹ 48,950.00

A21328 - Each of 1

₹ 48,950.00

In Stock

Quantity

1

Base Price: ₹ 48,950.00

GST (18%): ₹ 8,811.00

Total Price: ₹ 57,761.00

Antigen

Phosphatidylinositol 3,4,5-trisphosphate

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 0.1% BSA and 5mM sodium azide; pH 7.2

Host Species

Mouse

Purification Method

purified

Regulatory Status

RUO

Target Species

Chemical

Product Type

Antibody

Isotype

IgM

Applications

Immunocytochemistry

Clone

RC6F8

Conjugate

Unconjugated

Gene Alias

C12H24O22P4; phosphatidylinositol 3; phosphatidylinositol-3; PIP3

Immunogen

phosphatidylinositol 3,4,5-diphosphate

Quantity

100 μL

Primary or Secondary

Primary

Content And Storage

4° C

Form

Liquid

Target Molecule

Chemical

Description

  • Phosphatidylinositol (3, 4, 5)-trisphosphate (PtdIns(3, 4, 5)P3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol (4, 5)-bisphosphate
  • PtdIns (3, 4, 5) P3 is dephophosphorylated by the phosphatase, PTEN on the 3 position and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring
  • The PH domain in a number of proteins binds to PtdIns (3, 4, 5) P3
  • Such proteins include Akt/PKB, PDK1, Btk1 and ARNO
  • The generation of PtdIns (3, 4, 5) P3 at the plasma membrane upon the activation of class I PI 3-kinases causes these proteins to translocate to the plasma membrane and accordingly affects their activity
  • The PH domain allows binding between PtdIns (3, 4, 5) P3 and G-protein coupled receptor kinases (GRKs)
  • This enhances the binding of the GRK to the plasma membrane
  • [National Center for Biotechnology Information
  • PubChem Compound Database; CID=53477782]
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