MilliporeSigma™ Catechol O-methyltransferase/COMT, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | AB5873IMI-Each-of-1 | In Stock | ₹ 40,292.08 |
AB5873IMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
Catechol O-methyltransferase/COMT
Classification
Polyclonal
Conjugate
Unconjugated
Gene
COMT
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This polyclonal antibody was raised against a sequence present in both the membrane-bound (MB-COMT) and the soluble (S-COMT) spliced isoforms of human catechol O-methyltransferase reported by UniProt (P21964).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P21964
Immunogen
KLH-conjugated linear peptide corresponding to an extracellular domain sequence of human catechol O-methyltransferase.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_000745
Target Species
Human
Related Products
Description
- Catechol O-methyltransferase (EC 2.1.1.6; UniProt P21964) is encoded by the COMT gene (Gene ID 1312) in human
- Catechol-O-methyltransferase initiates the metabolic breakdown of catecholamines (including the neurotransmitters dopamine, epinephrine, and norepinephrine) by catalyzing the transfer of a methyl group from S-adenosylmethionine (SAM) to catecholamines in the presence Mg++
- This O-methylation results in one of the major degradative pathways of the catecholamine transmitters
- In addition to endogenous substances, COMT is also important in the metabolism of catechol drugs
- Two isoforms exist as a result of alternative initiation codon usage
- The membrane-bound isoform or MB-COMT contains a short N-terminal cytoplasmic tail (a.a
- 1-6), a transmembrane segment (a.a
- 7-26), and a large C-terminal extracellular region (a.a
- 27-271), while the soluble or S-COMT isoform lacks the N-terminal 50-amino acid sequence of MB-COMT
- MB-COMT and S-COMT differ in their substrate affinity and capacities
- Despite having a lower capacity than S-COMT, MB-COMT has around a 10-fold greater affinity for dopamine and noradrenaline, and therefore is likely to be better suited for metabolizing catecholamines at the concentrations found in brain
- The influence of the Val(158)Met polymorphic form of catechol-o-methyltransferase (COMT) on brain activation and functional connectivity is the subject of numerous studies.