ABA-220302
Leptin Monoclonal Antibody (3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABA-220302-Each-of-1 | In Stock | ₹ 85,573.50 |
ABA-220302 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 85,573.50
GST (18%): ₹ 15,403.23
Total Price: ₹ 1,00,976.73
Antigen
Leptin
Classification
Monoclonal
Concentration
0.98 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P41159
Gene Symbols
Lep
Immunogen
Purified, recombinant Leptin.
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
ELISA, Immunohistochemistry
Clone
3
Conjugate
Unconjugated
Gene
Lep
Gene Alias
CD295 antigen; H-Leptin; HuB219; Lep; LEPD; LEP-R; Leptin; leptin (murine obesity homolog); leptin (obesity homolog, mouse); leptin precursor; Method: conceptual translation supplied by author.; OB; obese; obese protein; obese, mouse, homolog of; obesity; obesity factor; obesity protein; OB-R; OBS; truncated leptin
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
3952
Content And Storage
4° C, store in dark
Form
Liquid
Related Products
Description
- ABS 022-03-02 detects Leptin in human samples
- ABS 022-03-02 has been successfully used in ELISA and immunohistochemistry procedures
- ABS 022-03-02 binds free Leptin in solution
- In sandwich ELISA, ABS 022-03-02 works as a capture antibody with ABS 022-11-02 as a detection antibody
- NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism and reproductive function
- Leptin is approximately 16 kDa in mass and encoded by the obese (ob) gene
- Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body
- Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta
- Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells
- Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure
- Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors
- Leptin promotes hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, influences pubertal development and fetal growth
- Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension
- Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation
- Severe hereditary obesity in rodents and humans can be caused by defects in leptin production.