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ABN147725UG

nSR100 (SRRM4), Rabbit anti-Mouse, Human, Polyclonal, Millipore Sigma™

Manufacturer: MilliporeSigma

Select a Size

Pack Size SKU Availability Price
Each of 1 ABN147725UG-Each-of-1 In Stock ₹ 17,118.26

ABN147725UG - Each of 1

₹ 17,118.26

In Stock

Quantity

1

Base Price: ₹ 17,118.26

GST (18%): ₹ 3,081.287

Total Price: ₹ 20,199.547

Antigen

nSR100 (SRRM4)

Classification

Polyclonal

Dilution

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected nSR100 (SRRM4) in mouse cerebral cortex and human cerebral cortex tissue sections.

Gene Alias

Serine/arginine repetitive matrix protein 4;Medulloblastoma antigen MU-MB-2.76;Neural-specific serine/arginine repetitive splicing factor of 100 kDa;Neural-specific SR-related protein of 100 kDa;nSR100

Host Species

Rabbit

Molecular Weight of Antigen

∽68 kDa observed; 68.56 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Quantity

25 μg

Research Discipline

Neuroscience

Test Specificity

This rabbit polyclonal antibody detects Serine/arginine repetitive matrix protein 4 in human and mouse cells. It targets an epitope within 104 amino acids from the C-terminal half.

Content And Storage

Stable for 1 year at 2-8°C from date of receipt.

Applications

Immunohistochemistry (Paraffin), Western Blot

Conjugate

Unconjugated

Formulation

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Gene Symbols

SRRM4;KIAA1853

Immunogen

GST/His-tagged recombinant frgment corresponding to 104 amino acids from the C-terminal half of human Serine/arginine repetitive matrix protein 4.

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Mouse, Human

Form

Purified

Description

  • Anti-nSR100 (SRRM4), Cat
  • No
  • ABN1477, is a highly specific rabbit polyclonal antibody that targets Serine/arginine repetitive matrix protein 4 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
  • Serine/arginine repetitive matrix protein 4 (UniProt: A7MD48; also known as Medulloblastoma antigen MU-MB-2.76, Neural-specific serine/arginine repetitive splicing factor of 100 kDa, Neural-specific SR-related protein of 100 kDa, nSR100) is encoded by the SRRM4 (also known as KIAA1853) gene (Gene ID: 84530) in human
  • nSR100 is a nuclear protein that is specifically expressed in neuronal cells
  • It serves as a splicing factor that is specifically required for neural cell differentiation
  • It acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promote neural-specific exon inclusion in many genes that function in neural cell differentiation
  • It is shown to regulate the splicing of protrudin gene (Zfyve27) transcripts in neuronal cells and promotes splicing of protrudin pre-mRNA so as to include a microexon (exon L) encoding seven amino acids in a neuron-specific manner
  • The resulting protein known as Protrudin-L promotes neurite outgrowth during neurogenesis
  • Depletion of nSR100 in Neuro2A cells is shown to impair neurite outgrowth, whereas its ablation in mouse embryos is reported to prevent differentiation of neuronal progenitors in the cortex and impair development of the central and peripheral nervous systems
  • (Ref.: Ohnishi, T et al
  • (2017)
  • Sci
  • Rep
  • 7: 41130; Quesnel-Vallières, M et al
  • (2015)
  • Genes Dev
  • 29(7); 746-759).