Home Products Antibodies Primary Antibodies ABS106825UL
ABS106825UL

Acetyl CoA Carboxylase 1, Rabbit anti-Human, Polyclonal, Millipore Sigma™

Manufacturer: MilliporeSigma

Select a Size

Pack Size SKU Availability Price
Each of 1 ABS106825UL-Each-of-1 In Stock ₹ 17,118.26

ABS106825UL - Each of 1

₹ 17,118.26

In Stock

Quantity

1

Base Price: ₹ 17,118.26

GST (18%): ₹ 3,081.287

Total Price: ₹ 20,199.547

Antigen

Acetyl CoA Carboxylase 1

Classification

Polyclonal

Dilution

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Acetyl CoA Carboxylase 1 in human liver and human kidney tissue sections.

Gene Alias

ACC1;ACC-alpha;EC 6.4.1.2

Host Species

Rabbit

Molecular Weight of Antigen

∽220 kDa observed; 265.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Quantity

25 μL

Research Discipline

Signaling

Test Specificity

This rabbit polyclonal antibody detects Acetyl-CoA carboxylase 1 in human cells. It targets an epitope within 245 amino acids from the C-terminal region.

Content And Storage

Stable for 1 year at 2-8°C from date of receipt.

Applications

Immunohistochemistry (Paraffin), Western Blot

Conjugate

Unconjugated

Formulation

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Gene Symbols

ACACA;ACC1;ACCA

Immunogen

GST-tagged recombinant fragment corresponding to 245 amino acids from the C-terminal half of human Acetyl-CoA carboxylase 1.

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Human

Description

  • Anti-Acetyl CoA Carboxylase 1, Cat
  • No
  • ABS1068, is a rabbit polyclonal antibody that detects Acetyl CoA Carboxylase 1 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
  • Acetyl-CoA carboxylase 1 (UniProt: Q13085; also known as EC: 6.4.1.2, ACC1, ACC-alpha) is encoded by the ACACA (also known as ACAC, ACC1, ACCA) gene (Gene ID: 31) in human
  • ACC1 is a cytoplasmic protein that is expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues
  • It is also expressed at low level in pulmonary tissue, but is not detected in the liver
  • ACC1 can be present as a monomer, homodimer, or homotetramer
  • It can also form filamentous polymers
  • Four isoforms of ACC1 have been described that are produced by alternative splicing
  • It catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids and carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase
  • The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification
  • ACC1 levels are regulated under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA
  • Mutations in ACACA gene can result in ACC1 deficiency and lead to error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.