MilliporeSigma™ Rabbit anti-Ribophorin I/RPN-I, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1587-Each-of-1 | In Stock | ₹ 40,292.08 |
ABS1587 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
Ribophorin I/RPN-I
Classification
Polyclonal
Gene Accession No.
P04843
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Canine, Human, Rat
Form
Serum
Applications
Western Blot
Formulation
Rabbit polyclonal serum with 0.05% sodium azide.
Gene Symbols
RPN1
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminal sequence of human Ribophorin I/RPN-I.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_002941
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
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Description
- Specifically detects Ribophorin I/RPN-I in Canine, Human, Rat samples, and it is validated for Western Blotting Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 (EC 2.4.99.18; UniProt P04843; also known as Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67kDa subunit, Ribophorin I, RPN-I, Ribophorin-1) is encoded by the RPN1 gene (Gene ID 6184) in human
- Ribophorin I is an ER transmembrane protein and a subunit of the mammalian Oligosaccharyltransferase (OST) complex
- Ribophorin I binds newly synthesized target proteins and delivers them to the catalytic core of the OST complex
- Association of ribophorin I with newly synthesized membrane proteins was observed after the exit of the nascent chain from the Sec61 translocon, and it was unaffected by the N-glycosylation status
- Ribophorin I is reported to preferentially interact with misfolded over native ribonuclease A
- In addition, Ribophorin I is shown to complex with another ER protein malectin and enhance malectin's ability to prevent the secretion of the folding-defective proteins.