MilliporeSigma™ HRD1, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1623MI-Each-of-1 | In Stock | ₹ 40,292.08 |
ABS1623MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
HRD1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SYVN1, HRD1, KIAA1810
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Immunogen sequence is present in all three spliced isoforms of human HRD1/SYVN1 reported by UniProt (Q86TM6).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 155mM NaCl, 50mM Tris-HCl pH 7.4 with 0.05% Sodium Azide and 10% glycerol.
Gene Accession No.
Q86TM6
Immunogen
Linear peptide corresponding to the C-terminal sequence of human HRD1.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_115807
Target Species
Human
Related Products
Description
- E3 ubiquitin-protein ligase synoviolin (UniProt Q86TM6; also known as Synovial apoptosis inhibitor 1) is encoded by the SYVN1 (also known as HRD1, KIAA1810) gene (Gene ID 84447) in human
- E3 ubiquitin-protein ligase synoviolin is a multi-transmembrane ER membrane protein
- Originally named Hrd1, synoviolin adopted the current name due to its upregulation in synovial fibroblasts from patients with rheumatoid arthritis as a result of exposure to inflammatory cytokines
- Synoviolin plays a protective role against ER stress-induced apoptosis by mediating not only the degradation of ER misfolded proteins, but also the degradation of proapoptotic protein p53 as well as IRE1α (inositol-requiring enzyme 1α), a critical kinase regulating ER stress-induced cell death
- Synoviolin is produced with a signal peptide (a.a
- 1-22) sequence, the removal of which yields the mature 5-transmembrane (a.a
- 42-62, 99-119, 141-161, 170-190, 225-245) protein, having its N-terminal end in the ER lumen (a.a
- 23-41) and C-terminal end (a.a
- 246-617) in the cytoplasm
- Its C-terminal cytoplasmic end contains the p53/TP53-interacting region (a.a
- 236-270), an atypical RING-type zinc finger domain (a.a
- 291-330), and a proline-rich region (a.a
- 339-478).