ABS1638MI
MilliporeSigma™ PDZK1, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1638MI-Each-of-1 | In Stock | ₹ 42,968.31 |
ABS1638MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
PDZK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PDZK1, CAP70, CLAMP, NHERF3, PDZD1
Host Species
Rabbit
Purification Method
Protein A Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with both spliced isoforms of human PDZK1 reported by UniProt (Q5T2W1).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q5T2W1
Immunogen
Full-length recombinant human PDZK1.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001188254
Target Species
Human
Form
Purified
Related Products
Description
- Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (UniProt Q5T2W1; also known as CFTR-associated protein of 70 kDa, Na/Pi cotransporter C-terminal-associated protein 1, Na(+)/H(+) exchanger regulatory factor 3, NaPi-Cap1, NHERF-3, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3) is encoded by the PDZK1 (also known as CAP70, CLAMP, NHERF3, PDZD1) gene (Gene ID 5174) in human
- PDZK1/NHERF-3 is an adaptor protein that regulates several membrane-transporting proteins, including cystic fibrosis transmembrane conductance regulator (CFTR), multidrug resistance protein 4 (MRP4), parathyroid 1 receptor, somatostatin receptors 1-5 (SSTRs), human prostacyclin receptor (hIPR), 2-adrenergic receptor ( 2AR), mGluR 5, purinergic receptor P2Y1, CCR5, opioid receptor, corticotropin-releasing factor receptor 1 (CRFR1) and serotonin 2A receptor (5-HT2AR)
- PDZK1/NHERF3 is predominantly expressed in epithelial and endothelial cells in the liver, kidney and small intestine, while lower level is also found at neuronal synapses
- PDZK1 overexpression selectively enhances CRFR1-stimulated ERK1/2 phosphorylation without affecting CRFR1 endocytosis, while PDZK1 negatively regulates 5-HT2AR endocytosis without affecting 5-HT2AR-mediated ERK1/2 phosphorylation
- Nherf3 gene knockout in mice results in profound reductions in Mrp4 expression and Mrp4-mediated drug transport in the kidney
- Nherf3-/- mice are also more prone to CFTR-mediated secretory diarrhea
- Human PDZK1 is a 519-amino acid protein with four PDZ (PSD-95/discs large/ZO-1) motifs (a.a
- 9-90, 134-215, 243-323, 378-458)
- Alternative splicing produces a 408-a.a
- isoform missing a.a
- 154-264.