MTNR1B, Rabbit anti-Human, Polyclonal, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABT189025UG-Each-of-1 | In Stock | ₹ 17,118.26 |
ABT189025UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 17,118.26
GST (18%): ₹ 3,081.287
Total Price: ₹ 20,199.547
Antigen
MTNR1B
Classification
Polyclonal
Dilution
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected MTNR1B in human retina tissue.
Gene Alias
Melatonin receptor type 1B;Mel-1B-R
Host Species
Rabbit
Molecular Weight of Antigen
40.19 kDa calculated.
Quantity
25 μg
Research Discipline
Cell Structure
Test Specificity
This rabbit polyclonal antibody detects Melatonin receptor type 1B in human.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
MTNR1B
Immunogen
KLH-conjugated linear peptide corresponding to 20 amino acids from the N-terminal region of human Melatonin receptor type 1B.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Related Products
Description
- Anti-MTNR1B Antibody, Cat
- No
- ABT1890, is a rabbit polyclonal antibody that detects MTNR1B and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
- Melatonin receptor type 1B (UniProt: P49286; also known as Mel-1B-R, Mel1b receptor) is encoded by the MTNR1B gene (Gene ID: 4544) in human
- Mel-1B-R is a member of the G-protein coupled 1 family that is predominantly expressed in retina and to lesser extent in brain tissue
- Mel-1B-R activity is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity
- Mel-1B-R mediates the reproductive and circadian actions of melatonin
- Melatonin is shown to be involved in body mass regulation in mammals and this effect is suggest to be mediated by a direct action of melatonin on Mel-1B receptors on brown adipocytes
- Melatonin is reported to act as a chemopreventive agent and its levels inversely correlate with the risk of developing cancer
- In this regard melatonin induces p38-dependent phosphorylation of both p53 and histone H2AX
- Activation of the p53-dependent DNA damage response by melatonin is mediated by both Mel-1A and Mel-1B receptors
- The absence of either receptor impairs melatonin's ability to reduce both cell proliferation and clonogenic potential of cancer cells
- A variant in MTNR1B gene is reported to worsen the deleterious effect of melatonin on glucose tolerance in humans
- (Ref.: Brydon, L
- et al
- (2001)
- Endocrinology
- 142(10):4264-4271; Santoro, R., et al
- (2013)
- Carcinogenesis
- 34(5):1051-1061).