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AMPA6618

BRCA1 Monoclonal Antibody (KEN), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 AMPA6618-Each-of-1 In Stock ₹ 53,311.00

AMPA6618 - Each of 1

₹ 53,311.00

In Stock

Quantity

1

Base Price: ₹ 53,311.00

GST (18%): ₹ 9,595.98

Total Price: ₹ 62,906.98

Antigen

BRCA1

Classification

Monoclonal

Concentration

1.5 mg/mL

Formulation

PBS with 0.05% sodium azide

Gene Accession No.

P38398

Gene Symbols

BRCA1

Immunogen

Human BRCA1 containing residues 1314-1864.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG3 κ

Applications

Immunocytochemistry, Immunoprecipitation, Western Blot

Clone

KEN

Conjugate

Unconjugated

Gene

BRCA1

Gene Alias

brca 1; Brca1; brca-1; BRCA1, DNA repair associated; BRCA1/BRCA2-containing complex, subunit 1; BRCAI; BRCC1; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein 1; breast cancer 1; breast cancer 1 early onset; breast cancer 1, early onset; breast cancer associated 1; breast cancer type 1 susceptibility protein; Breast cancer type 1 susceptibility protein homolog; BROVCA1; BROVCA12; Delta772-3095; early onset breast cancer 1; Fanconi anemia, complementation group S; FANCS; IRIS; OTTHUMP00000212147; OTTHUMP00000212148; OTTHUMP00000212149; OTTHUMP00000212150; OTTHUMP00000212151; OTTHUMP00000212155; PNCA4; PPP1R53; protein phosphatase 1, regulatory subunit 53; PSCP; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1; RNF53; truncated BRCA1; truncated breast and ovarian cancer susceptibility protein 1; truncated breast and ovarian cancer sususceptibility protein 1; truncated breast cancer type 1 susceptibility protein

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

672

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Description

  • Suggested positive control: U2OS and MCF-7 whole cell lysates
  • BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex)
  • BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex
  • The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination
  • Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers
  • Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene
  • Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described
  • A related pseudogene, which is also located on chromosome 17, has been identified.