DIABLO Monoclonal Antibody (78-1-118), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | AMPA6846-Each-of-1 | In Stock | ₹ 59,185.00 |
AMPA6846 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 59,185.00
GST (18%): ₹ 10,653.30
Total Price: ₹ 69,838.30
Antigen
DIABLO
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.1% sodium azide
Gene Accession No.
Q9JIQ3, Q9NR28
Gene Symbols
DIABLO
Immunogen
Recombinant mature human Smac/DIABLO (lacks amino acids 1-55 present in Smac/DIABLO precursor)
Regulatory Status
RUO
Gene ID (Entrez)
288753, 56616, 66593
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
78-1-118
Conjugate
Unconjugated
Gene
DIABLO
Gene Alias
0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3
Host Species
Mouse
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1, IgG3
Related Products
Description
- Suggested positive control: 293 whole cell lysate
- DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis
- This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins
- Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events
- Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders
- Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol
- The release of these proteins, however, occurs via different mechanisms
- Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).