BDB340507
PAC-1 Mouse anti-Human, FITC, Clone: PAC-1, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB340507-Each-of-1 | In Stock | ₹ 27,056.00 |
BDB340507 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,056.00
GST (18%): ₹ 4,870.08
Total Price: ₹ 31,926.08
Antigen
PAC-1
Classification
Monoclonal
Concentration
25μg/mL
Formulation
Phosphate buffered saline with gelatin and 0.1% sodium azide.
Immunogen
Human platelets
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store vials at 2-8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.
Applications
Flow Cytometry
Clone
PAC-1
Conjugate
FITC
Host Species
Mouse
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgM κ
Related Products
Description
- PAC-1 recognizes an epitope on the glycoprotein IIb/IIIa (gpIIb/IIIa, aIIbb3) complex of activated platelets at or near the platelet fibrinogen receptor
- The gpIIb/IIIa complex is a member of a family of heterodimeric adhesive protein receptors found on a variety of cell types that have been named the integrin or the cytoadhesion family.The gpIIb/IIIa complex is located on the surface membrane of resting platelets
- Platelet activation induces a calcium-dependent conformational change in gpIIb/IIIa that exposes a ligand binding site
- Four adhesive macromolecules are capable of interacting with the activated form of gpIIb/IIIa: fibrinogen, von Willebrand factor (vWf), fibronectin, and vitronectin
- The binding of fibrinogen to the gpIIb/IIIa receptor is required for platelet aggregation
- PAC-1 binds only to activated platelets and appears to be specific for this recognition site within gpIIb/IIIa
- Approximately 45,000 to 50,000 gpIIb/IIIa receptors appear on the platelet surface upon activation
- PAC-1 inhibits fibrinogen- mediated platelet aggregation
- Flow Cytometry