BDB550515
CD253 Mouse anti-Human, Unlabeled, Clone: RIK-2, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB550515-Each-of-1 | In Stock | ₹ 29,904.00 |
BDB550515 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 29,904.00
GST (18%): ₹ 5,382.72
Total Price: ₹ 35,286.72
Antigen
CD253
Classification
Monoclonal
Concentration
0.5mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Human TRAIL
Quantity
0.1 mg
Research Discipline
Immunology
Target Species
Human
Isotype
IgG1
Applications
Flow Cytometry
Clone
RIK-2
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Related Products
Description
- The RIK-2 monoclonal antibody specifically binds to CD253 which is also known as TRAIL (TNF-Related Apoptosis-Inducing Ligand) and Apo2 ligand (APO-2L)
- CD253 is a member of the Tumor Necrosis Factor Superfamily and is encoded by the TNFSF10 gene
- CD253 is a type II membrane protein that may be expressed as a full-length, cell surface associated protein as well as in a soluble form
- Both surface and soluble forms of TRAIL rapidly induce apoptosis by a wide range of cell lines but not by normal cells
- TRAIL is expressed by activated T cells, NK cells, dendritic cells, monocytes and by a variety of non-lymphoid cells
- TRAIL can bind to and exert apoptosis through DR4 (TRAIL-R1) and DR5 (TRAIL-R2) receptors
- It can also bind to decoy receptors, including DcR1/TRID/TRAIL-R3 and DcR2/TRUNDD/TRAIL-R4, and possibly OPG/TNFRSF11B, which may serve to regulate TRAIL activity
- TRAIL has been shown to be involved in T cell-mediated cytotoxicity, however its mechanism of action remains to be fully elucidated
- The RIK-2 clone was selected based on its ability to block TRAIL-mediated cytotoxic activity.