BDB551890
CD180 Mouse anti-Human, Unlabeled, Clone: G28-8, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB551890-Each-of-1 | In Stock | ₹ 24,163.50 |
BDB551890 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,163.50
GST (18%): ₹ 4,349.43
Total Price: ₹ 28,512.93
Antigen
CD180
Classification
Monoclonal
Concentration
0.5mg/mL
Description
RP105
Host Species
Mouse
Quantity
0.1 mg
Research Discipline
Immunology
Target Species
Human
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
G28-8
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
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Description
- Reacts with RP105/Bgp95, a 95-105 kDa type I membrane protein consisting of extracellular leucine-rich repeats and a short cytoplasmic domain
- It is expressed on mantle zone B cells, but weakly on germinal center B cells
- RP105/Bgp95 is also expressed on peripheral blood monocytes, dendritic cells, and a subset of peripheral blood lymphocytes
- The extracellular domain associates with a molecule called MD-1 to form a cell surface receptor complex RP105/Bgp95/MD- 1
- This receptor belongs to the family of toll-like receptors (TLR)
- Studies show that RP105/Bgp95/MD-1, working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS)
- Reports on functional studies show that G28-8 monoclonal antibody can induce a G0 to G1 cell cycle transition and was synergistic with PMA, anti-µ, or anti-CD40 in inducing proliferation of resting B cells.