BDB553340
CD11a Rat anti-Mouse, FITC, Clone: M17/4, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB553340-Each-of-1 | In Stock | ₹ 40,762.00 |
BDB553340 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,762.00
GST (18%): ₹ 7,337.16
Total Price: ₹ 48,099.16
Antigen
CD11a
Classification
Monoclonal
Concentration
0.5mg/mL
Description
Itgal; Integrin alpha-L; Integrin αL; ITAL; LFA-1A; LFA-1α; Ly-15
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
M17/4
Conjugate
FITC
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
C57BL/6 Mouse Splenic Secondary Cytotoxic T Lymphocytes
Quantity
0.5 mg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The M17/4 antibody reacts with the 180 kDa αL chain of LFA-1 (CD11a/CD18, αLβ2 integrin), a heterodimeric surface glycoprotein expressed on almost all leukocytes
- CD8a+CD8b- intestinal intraepithelial T lymphocytes, which are believed to be thymus independent, do not express CD11a
- LFA-1 mediates a variety of heterotypic and homotypic intercellular adhesions through interaction with ICAM-1 (CD54) and ICAM-2 (CD102), including participation in the immunological synapses between CD8+ T lymphocytes and antigen-presenting cells
- mAb M17/4 blocks a variety of LFA-1-mediated cells interactions in vitro, and costimulatory effects have also been described
- In vivo treatment with M17/4 mAb reduces the severity of graft-versus-host reactions, prolongs allograft survival, inhibits the development of autoimmunity, and blocks substance P-induced leukocyte migration
- The M17/4 and 2D7 (Cat
- No
- 553120) antibodies are reported to recognize different epitopes of the CD11a molecule.