BDB553787
CD40 Rat anti-Mouse, NA/LE, Unlabeled, Clone: 3/23, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB553787-Each-of-1 | In Stock | ₹ 35,066.00 |
BDB553787 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,066.00
GST (18%): ₹ 6,311.88
Total Price: ₹ 41,377.88
Antigen
CD40
Classification
Monoclonal
Concentration
1.0mg/mL
Formulation
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Immunogen
Mouse CD40 Recombinant Protein
Quantity
0.5 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
3/23
Conjugate
Unconjugated
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Related Products
Description
- The 3/23 clone reacts with CD40, a 40-50kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells
- CD40 has been reported to be transiently expressed on activated CD4+ and CD8+ T cells and in some mouse strains, the 3/23 mAb has been reported to react with 5-10% of T lymphocytes in adult mouse, but not neonatal, spleen
- CD40 plays a key role in B-cell growth and differentiation where interactions of CD40 with its ligand, CD154, are involved in the initiation, effector, and memory stages of cell-mediated immune responses
- In addition, CD40 has been reported to be involved with the triggering of NK cells and NK-T cells
- Ligation of CD40 with the 3/23 antibody has been reported to induce splenic B cells to express the costimulatory molecule CD86 (B7-2)
- In addition, although the 3/23 antibody by itself is a weak B-cell mitogen, it has been reported to synergize markedly with mitogenic anti-IgM, anti-IgD mAb or IL-4 to promote B-cell proliferation.