BDB555286
CD70 Rat anti-Mouse, PE, Clone: FR70, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB555286-Each-of-1 | In Stock | ₹ 22,962.00 |
BDB555286 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 22,962.00
GST (18%): ₹ 4,133.16
Total Price: ₹ 27,095.16
Antigen
CD70
Classification
Monoclonal
Concentration
0.2mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
BALB/c mouse B lymphoma A202J
Quantity
0.1 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2b κ
Applications
Flow Cytometry
Clone
FR70
Conjugate
PE
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33-kDa type-II transmembrane glycoprotein belonging to the TNF/NGF superfamily
- CD70 is the ligand for CD27 and is expressed primarily on activated B cells
- CD70 expression can be induced by activation of splenocytes with lipopolysaccharide and stimulatory antibodies specific for IgM, CD40 or both
- mRNA coding for CD70 is transiently expressed after Concanavalin A stimulation of splenocytes or thymocytes
- CD70 has been observed to be expressed on dendritic cells of Leishmania major-infected mice
- The CD27-CD70 interaction delivers costimulatory signals to T cells and NK cells
- It has been reported that FR70 antibody blocks binding of mCD27-Ig fusion protein to mouse Cd70-transfected cells and inhibits some in vitro T-cell- and NK-cell-dependent responses
- R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae
- It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule
- This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.