Tau Mouse anti-Rat, Unlabeled, Clone: TAU-5, BD

Description

• Tau proteins are microtuble-associated proteins (MAPs) that are thought to function by stabilizing microtubles
• They comprise a family of multiple polypeptides that originate from one gene
• Alternate splicing of Tau mRNA and differential phosphorylation contribute to the heterogeneity of Tau
• Typically, Tau proteins migrate between ∽45-70kDa with isoelectric points ranging from 6.5-8.0
• Tau expression is widespread in the brain and is found in most cell types within the mammalian central nervous system
• Tau has a complex biochemical nature that is partly due to its many isoforms
• The number and molecular weights of Tau forms changes during brain development
• Additionally, the molecular wieghts and forms of Tau proteins at a given point of development vary between species
• Antibodies directed against different epitopes have been used to distinguish between Tau forms
• The monoclonal antibody TAU-5 recognizes a phosphorylation-independent epitope on Tau proteins
• The reduced molecular weight of Tau proteins may range between 45kDa to 95kDa
• The TAU-5 antibody reacts with a phosphorylation-independent epitope in the middle of tau
• It recognizes both the phosphorylated and non-phosphorylated form of Tau
• The antibody has been characterized in rat tissue
• Host Species: Mouse Clone: TAU-5 Isotype: IgG1 Species Reactivity: Rat Immunohistochemistry, Western Blotting