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BDB558034

Btk (pY551) and Itk (pY511) Mouse, Unlabeled, Clone: 24A/BTK (Y551), BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB558034-Each-of-1 In Stock ₹ 54,156.50

BDB558034 - Each of 1

₹ 54,156.50

In Stock

Quantity

1

Base Price: ₹ 54,156.50

GST (18%): ₹ 9,748.17

Total Price: ₹ 63,904.67

Antigen

Btk (pY551) and Itk (pY511)

Classification

Monoclonal

Concentration

0.5mg/mL

Description

ATK; BPK; AGMX1

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Isotype

IgG1 κ

Applications

Western Blot

Clone

24A/BTK (Y551)

Conjugate

Unconjugated

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Immunogen

Phosphorylated Human Btk Peptide

Quantity

0.1 mg

Research Discipline

Cell Biology

Content And Storage

Store undiluted at 4°C

Description

  • B ruton's t yrosine k inase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling
  • The activity of Btk is regulated by Src mediated phosphorylation of the kinase domain at tyrosine 551 (Y551)
  • This event induces Btk kinase activity and subsequent autophosphorylation at Y223
  • Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate
  • γ1 (PLC γ1), a key regulator of calcium mobilization and extracellular signal-regulated kinase (ERK) activation
  • Itk is regulated by an activating transphosphorylation event in which Y511 in the kinase domain is phosphorylated by Lck
  • The 24a/BTK (Y551) monoclonal antibody recognizes the Y551-phosphorylated form of human Btk and the Y511 phosphorylated form of human Itk.