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BDB558122

CD16 Mouse anti-Human, Pacific Blue, Clone: 3G8, BD

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB558122-Each-of-1 In Stock ₹ 33,464.00

BDB558122 - Each of 1

₹ 33,464.00

In Stock

Quantity

1

Base Price: ₹ 33,464.00

GST (18%): ₹ 6,023.52

Total Price: ₹ 39,487.52

Antigen

CD16

Classification

Monoclonal

Concentration

0.2mg/mL

Description

FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications

Flow Cytometry

Clone

3G8

Conjugate

Pacific Blue

Formulation

Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.

Immunogen

Human polymorphonuclear leukocytes

Quantity

0.1 mg

Research Discipline

Immunology

Target Species

Baboon, Cynomolgus, Human, Rhesus Monkey

Isotype

IgG1 κ

Description

  • The 3G8 monoclonal antibody specifically binds to the 50-65 kDa transmembrane form of the IgG Fc Receptor (FcγRIII), a human NK cell-associated antigen
  • CD16 is expressed on NK cells as well as macrophages and granulocytes
  • Reports indicate that CD16 plays a role in signal transduction and NK cell activation
  • The 3G8 antibody blocks the binding of soluble immune complexes to granulocytes
  • The 3G8 antibody is reported (Vossebeld et al ., 1997) to increase intracellular calcium levels in human neutrophils by interacting with bothFcγRIIa and FcγRIIIb molecules
  • This antibody has also been reported to induce homotypic neutrophil aggregation
  • This clone also cross-reacts with a subset of peripheral blood lymphocytes and monocytes, but not granulocytes, of baboon and both rhesus and cynomologus macaque monkeys
  • Multi-color analysis reveals that the distribution on lymphocytes is similar to that found in human studies with the majority of CD16-positive lymphocytes being both CD3 and CD20 negative.