BDB558137
Stat4 (pY693) Mouse, Alexa Fluor 647, Clone: 38/P-STAT4, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558137-Each-of-1 | In Stock | ₹ 28,257.50 |
BDB558137 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 28,257.50
GST (18%): ₹ 5,086.35
Total Price: ₹ 33,343.85
Antigen
Stat4 (pY693)
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Formulation
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human Stat4 (pY693)
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human, Mouse
Isotype
IgG2b κ
Applications
Flow Cytometry
Clone
38/P-STAT4
Description
Signal transducer and activator of transcription 4; SLEB11
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription
- Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6
- Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset
- Stat4 is activated by IL-12 and by type 1 interferons
- Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNγ in response to treatment with IL-12
- IFNγ plays an important role in host defense
- A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation
- IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721
- Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated
- Host Species: Mouse Clone: 38 Isotype: IgG2b κ Species Reactivity: Human Immunogen: Phosphorylated Human Stat4 (pY693) Flow Cytometry, Intracellular Staining