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BDB558408

CD337 (NKp30) Mouse anti-Human, Alexa Fluor 647, Clone: P30-15, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB558408-Each-of-1 In Stock ₹ 28,124.00

BDB558408 - Each of 1

₹ 28,124.00

In Stock

Quantity

1

Base Price: ₹ 28,124.00

GST (18%): ₹ 5,062.32

Total Price: ₹ 33,186.32

Antigen

CD337

Classification

Monoclonal

Concentration

0.2mg/mL

Formulation

Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.

Immunogen

Human NKp30 e tracellular domain

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications

Flow Cytometry

Clone

P30-15

Conjugate

Alexa Fluor 647

Host Species

Mouse

Quantity

0.1 mg

Research Discipline

Immunology

Target Species

Human

Isotype

IgG1 κ

Description

  • The monoclonal antibody clone p30-15 reacts with CD337, also known as NKp30, a receptor found on the surface of natural killer (NK) cells
  • NK cells are large lymphoid cells discovered because of their ability to recognize and kill abnormal cells such as tumor and virally infected cells
  • NK cell immune responses are regulated by a balance of activating and inhibitory signals generated by cell surface receptors
  • Inhibitory receptors recognize MHC class I molecules on normal cells producing a negative signal to the NK cell
  • Loss of MHC class I expression in infected or transformed cells results in the loss of this negative signal leading to NK cell activation
  • In concert with the loss of inhibitory signals, activation signals via NK receptors such as NKp30, NKp44, NKp46, NKG2D, and NKp80 mediate the activation of NK cells
  • NKp30 cooperates with NKp46 and/or NKp44 in the induction of NK cell-mediated cytotoxicity against the majority of target cells.