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BDB558414

CD267 Rat anti-Human, PE, Clone: 1A1-K21-M22, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB558414-Each-of-1 In Stock ₹ 33,108.00

BDB558414 - Each of 1

₹ 33,108.00

In Stock

Quantity

1

Base Price: ₹ 33,108.00

GST (18%): ₹ 5,959.44

Total Price: ₹ 39,067.44

Antigen

CD267

Classification

Monoclonal

Concentration

0.2mg/mL

Description

TACI; TNFRSF13B; Tumor necrosis factor receptor 13B; TNFRSF14B2; CVID2

Host Species

Rat

Quantity

0.1 mg

Research Discipline

Immunology

Target Species

Human

Isotype

IgG2a κ

Applications

Flow Cytometry

Clone

1A1-K21-M22

Conjugate

PE

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Immunogen

Human RBL

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Description

  • The 1A1-K21-M22 monoclonal antibody specifically binds to CD267 which is also known as TACI (Transmembrane Activator and CAML Interactor)
  • CD267 is a member of the of the Tumor Necrosis Factor Receptor (TNFR) Superfamily and is encoded by the TNFRSF13B gene
  • This 32 kDa type III transmembrane protein receptor binds to the ligands, BAFF (TNFSF13B/BLyS/CD257) and APRIL (TNFSF13/CD256)
  • Ligand-bound CD267 transduces signals leading to the activation of transcription factors including NFAT, AP1, and NF-kappa-B
  • CD267 is expressed most notably on maturing subsets of B cells and myeloma cells
  • In CD267 deficient mice, B cell numbers are increased and mice develop autoimmune disorders suggesting that CD267 plays an important role in the regulation of B cell homeostasis.