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BDB558532

RAB27 Mouse anti-Human, Unlabeled, Clone: 20.1/RAB27, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB558532-Each-of-1 In Stock ₹ 32,707.50

BDB558532 - Each of 1

₹ 32,707.50

In Stock

Quantity

1

Base Price: ₹ 32,707.50

GST (18%): ₹ 5,887.35

Total Price: ₹ 38,594.85

Antigen

RAB27

Classification

Monoclonal

Concentration

0.5mg/mL

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Immunogen

Human Rab27A Recombinant Protein

Quantity

0.1 mg

Research Discipline

Cell Biology

Target Species

Human

Isotype

IgG1 κ

Applications

Western Blot

Clone

20.1/RAB27

Conjugate

Unconjugated

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C

Description

  • Members of the Rab family of GTPases are non-transforming, membrane-bound, geranylgeranylated members of the Ras superfamily that are involved in the fusion and trafficking of cellular vesicles
  • Rab27A is expressed in many human tissues and it regulates the secreation of several types of cellular vesicles, such as melanosomes, insulin granules of pancreatic beta cells, and lytic granules of cytotoxic T lymphocytes
  • Rab27A is able to regulate such diverse processes by interacting with organelle-specific effector proteins, including melanophilin, granuphilin, and Munc13-4, respectively
  • Defects in Rab27A function are associated with the human diseases choroideremia and Griscelli syndrome 2 and the ashen mutant mouse
  • Rab27B is not so widely expressed, yet it is reported to have similar functional capacities as Rab27A
  • The 20.1 monoclonal antibody recognizes human Rab27A; cross-reactivity with Rab27B is unknown
  • Western Blotting