Cyclin C Rabbit, Unlabeled, Polyclonal, BD

Description

• Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes
• Cyclins contain a conserved amino acid sequence motif, the cyclin box, which allows their binding to cdks to form active complexes that regulate progression of the cell cycle
• More recently, cyclins are being shown to have additional functions not restricted to cell cycle regulation
• Thus, cyclins have been placed into functional groups as follows: Group 1 cyclins (A, B, D1, D2, D3, E and F) function primarily in cell cycle reguation; Group 2 cyclins (C and H) also play a role in transcriptional regulation; Group 3 cyclins (G1, G2 and I) may play a role distinct from either cell cycle or transcriptional regulation
• Cyclin C has been identified in both human and chicken species
• Like many cyclins, the expression of cyclin C oscillates throughout the cell cycle, with a peak observed during G1 phase
• Cyclin C may play a dual role within the cell in its ability to regulate both cell cycle progression as well as gene transcription
• Cyclin C associates with Cdk8, forming a complex which can induce gene transcription of Cdc2 (Cdk1)
• Because Cdc2 kinase is important for cell entry into mitosis, cyclin C's ability to regulate cell cycle progression may be attributed, in part, to modulation of Cdc2 protein expression.6 Cyclin C has a predicted molecular weight of 36kDa
• The polyclonal antiserum reacts with human and mouse cyclin C
• A polypeptide fragment containing amino acids 290-303 (QGPNGSQNSSYSQS) at the C-terminus of human cyclin C, with the addition of a C-terminal cysteine (C) residue to facilitate conjugation to KLH, was used as immunogen
• Immunoprecipitation, Western Blotting